|GD - Online||B. Gabard: Corneosurfametry|
|Printversion or Abstracts 2001|
a simple method to investigate the mildness
of cleansing products
Department of Biopharmacy, Spirig Pharma Ltd., CH-4622 Egerkingen, Switzerland
Irritant reactions to surfactants, cleansing products, soaps or detergents are common in clinical and occupational dermatology. The repeated use of such products may damage the skin, drying out the Stratum corneum and may cause irritant contact dermatitis. Mildness benefit has become a major claim, even overriding the primary purpose of the products, i.e. the cleansing benefit. Testing for mildness now ranks among the First concerns of the manufacturing industry. A wealth of publications deals with the clinical testing of cutaneous tolerance, trying to improve the methodology, to reduce the costs of testing and to facilitate decision-making. Differences can be assessed by clinical and/or instrumental assessment. However, this may be difficult as commercially available products are generally safe to use and none are harsh in the absolute sense. Fine ranking is difficult, if not impossible.
The mildness of 19 different syndets and shampoos, all claimed to be "mild"
or "suitable for Babies", was evaluated with two methods in vivo (flex
wash test, soap chamber test) and with a new one in vitro, corneosurfametry. For
this purpose, the calculation of an index of irritation (IOI) was proposed. Na-laurylsulfate
was used as a standard and as a model surfactant in each test. Bioengineering
methods (skin colour, transepidermal water loss TEWL) were used throughout.
Corneosurfametry emerged as simple, low-cost and fast new technique for ranking different materials according to their mildness. However, the skin bioengineering techniques showed that some products could lead to measurable skin reactions such as erythema. Thus, corneosurfametry should not be used alone, but should be combined with a suitable in vivo test.
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